反应详情

A mixture of 3-(2-morpholino-2-thioxoethyl)-2-phenylpyrazolo[1,5-a]pyridine (5.50 g), potassium hydroxide (85%, 6.45 g) and water (44 ml) was refluxed for 14 hours. After cooling, the reaction mixture was poured onto ice (110 g) and acidified with 6N-hydrochloric acid (pH ≈2) and the resulting precipitates were collected to give 2-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)acetic acid (4.20 g).

1. temperaturewas refluxed for 14 hours
2. temperatureAfter cooling
3. additionthe reaction mixture was poured onto ice (110 g)
4. customthe resulting precipitates
5. customwere collected