1-(3-Aminopropyl)-4-methylpiperazine → HCID 15713323, compound

HRID 704079Notes

Reaction equation

HRID 704079 reaction equation
Cl[C:2]1[C:7]2[CH:8]=[C:9]3[N:14]([C:6]=2[C:5]([CH3:15])=[N:4][N:3]=1)[CH:13]=[CH:12][CH:11]=[CH:10]3.[CH3:16][N:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][NH2:26])[CH2:19][CH2:18]1>>[CH3:15][C:5]1[N:4]=[N:3][C:2]([NH:26][CH2:25][CH2:24][CH2:23][N:20]2[CH2:19][CH2:18][N:17]([CH3:16])[CH2:22][CH2:21]2)=[C:7]2[C:6]=1[N:14]1[C:9]([CH:10]=[CH:11][CH:12]=[CH:13]1)=[CH:8]2

Participants

3

Reactant 2

HCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 157133121-Chloro-4-methylpyridazino[4,5-b]indolizine

Product 1

HCID 15713323HCID 15713323, compound

Procedure

Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 10 equivalents of 4-methyl-1-(3-aminopropyl)piperazine at 150° C. gave the title compound as the free base (yellow solid, 16% of theory) after purification by HPLC and trituration with i-propylether, mp 60° C. (foams). The free base was converted to the trihydrochloride salt mp. 280° C., 275° C. shrink (hydroscopic).

Sources & evidence

ORD record
ord-6b44086b92cd473f8356b9dbce44c1b5
Source dataset
uspto-grants-1991_01
Patent number
US04985560

Reaction notes

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