1-(3-Aminopropyl)-4-methylpiperazine → HCID 15713323, compound

Participants

Reaction Steps

Following the procedure of Example 1, reaction of one equivalent of 1-chloro-4-methylpyridazino[4,5-b]indolizine and 10 equivalents of 4-methyl-1-(3-aminopropyl)piperazine at 150° C. gave the title compound as the free base (yellow solid, 16% of theory) after purification by HPLC and trituration with i-propylether, mp 60° C. (foams). The free base was converted to the trihydrochloride salt mp. 280° C., 275° C. shrink (hydroscopic).

Provenance & Evidence