反应详情

温度

20 °C

To a solution of nitromethane (0.67 g, 11 mmol) in 0.3 ml of 16% NH3 /MeOH, 1,7-dichloro-4-heptanone (0.50 g, 2.7 mmol) was added dropwise at 20° C. The resulting solution was stirred for 24 hours at 20° C. under ammonia gas atmosphere. The reaction mixture was concentrated and 0.1N NaOH was added to the residue to extract with methylene chloride. The extract was dried over anhydrous sodium sulfate, concentrated and distilled in vacuo to afford 0.42 g of the desired compound (Yield: 90%).

1. concentrationThe reaction mixture was concentrated
2. addition0.1N NaOH was added to the residue
3. extractionto extract with methylene chloride
4. dry with materialThe extract was dried over anhydrous sodium sulfate
5. concentrationconcentrated
6. distillationdistilled in vacuo