Potassium Fluoride → HCID 22149763, compound

Participants

Reaction Steps

Into a 1 l glass reactor equipped with a condenser, 251.0 g (1 mol) of isopropyl 2,4-dichloro-5-fluorobenzoate, 87 g (1.5 mol) of spray-dried potassium fluoride, 25.1 g of tetramethyl ammonium chloride and 500 g of sulforane were charged and reacted at 150° C. for 9 hours under vigorous stirring. After cooling, the inorganic salt was removed by filtration, and the filtrate was distilled under reduced pressure to obtain 199.8 g (yield: 85.2%) of isopropyl 2-chloro-4,5-difluorobenzoate. This compound was analyzed, and the results are as follows.

Provenance & Evidence