Potassium Fluoride → HCID 22149763, compound

HRID 704111Notes

Reaction equation

HRID 704111 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12](Cl)[C:11]([F:15])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[F-:16].[K+]>[Cl-].C[N+](C)(C)C>[Cl:1][C:2]1[CH:13]=[C:12]([F:16])[C:11]([F:15])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 522689Potassium FluorideHCID 22149749HCID 22149749, compound

Product 1

HCID 22149763HCID 22149763, compoundYield 85.2%

Reagents, catalysts & solvents 1

HCID 6379Tetramethylammonium chlorideCatalyst

Procedure

Into a 1 l glass reactor equipped with a condenser, 251.0 g (1 mol) of isopropyl 2,4-dichloro-5-fluorobenzoate, 87 g (1.5 mol) of spray-dried potassium fluoride, 25.1 g of tetramethyl ammonium chloride and 500 g of sulforane were charged and reacted at 150° C. for 9 hours under vigorous stirring. After cooling, the inorganic salt was removed by filtration, and the filtrate was distilled under reduced pressure to obtain 199.8 g (yield: 85.2%) of isopropyl 2-chloro-4,5-difluorobenzoate. This compound was analyzed, and the results are as follows.

Workup

  1. customInto a 1 l glass reactor equipped with a condenser
  2. customreacted at 150° C. for 9 hours under vigorous stirring
  3. temperatureAfter cooling
  4. customthe inorganic salt was removed by filtration
  5. distillationthe filtrate was distilled under reduced pressure

Sources & evidence

ORD record
ord-e87e689d58814f0db9797f1ea68ba1f3
Source dataset
uspto-grants-1991_01
Patent number
US04985588

Reaction notes

Loading…