Potassium Fluoride → HCID 22149758, compound

Participants

Reaction Steps

Into a 1 l glass reactor equipped with a condenser, 238.5 g (1 mol) of 2,2,2-trifluoroethyl 2-chlorobenzoate, 87 g (1.5 mol) of spray dried potassium fluoride, 23.9 g of tetrabutyl phosphonium bromide and 480 g of sulforane were charged and reacted at 180° C. for 20 hours under vigorous stirring. After cooling, the inorganic salt was removed by filtration, and the filtrate was distilled under reduced pressure to obtain 134.3 g (yield: 60.5%) of 2,2,2-trifluoroethyl 2-fluorobenzoate.

Provenance & Evidence