Potassium Fluoride → HCID 22149758, compound

HRID 704113Notes

Reaction equation

HRID 704113 reaction equation
Cl[C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([O:6][CH2:7][C:8]([F:11])([F:10])[F:9])=[O:5].[F-:16].[K+]>[Br-].C([P+](CCCC)(CCCC)CCCC)CCC>[F:16][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([O:6][CH2:7][C:8]([F:11])([F:10])[F:9])=[O:5]

Participants

4

Reactant 2

HCID 522689Potassium FluorideHCID 22149761HCID 22149761, compound

Product 1

HCID 22149758HCID 22149758, compoundYield 60.5%

Reagents, catalysts & solvents 1

HCID 76564Tetrabutylphosphonium bromideCatalyst

Procedure

Into a 1 l glass reactor equipped with a condenser, 238.5 g (1 mol) of 2,2,2-trifluoroethyl 2-chlorobenzoate, 87 g (1.5 mol) of spray dried potassium fluoride, 23.9 g of tetrabutyl phosphonium bromide and 480 g of sulforane were charged and reacted at 180° C. for 20 hours under vigorous stirring. After cooling, the inorganic salt was removed by filtration, and the filtrate was distilled under reduced pressure to obtain 134.3 g (yield: 60.5%) of 2,2,2-trifluoroethyl 2-fluorobenzoate.

Workup

  1. customInto a 1 l glass reactor equipped with a condenser
  2. customreacted at 180° C. for 20 hours under vigorous stirring
  3. temperatureAfter cooling
  4. customthe inorganic salt was removed by filtration
  5. distillationthe filtrate was distilled under reduced pressure

Sources & evidence

ORD record
ord-ec4aa815429040108621cb3a5c11a65e
Source dataset
uspto-grants-1991_01
Patent number
US04985588

Reaction notes

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