反应详情

2-Benzyloxymethyl-2-cyclohexyl-propan-1,3-diol (5.5 g.) in dry diethyl ether (50 ml.) was added to liquid ammonia (200 ml) at -70°. Sodium (2.5 g.) was added to the stirred solution. Stirring was maintained at -70°, for 1 hour. The mixture was allowed to warm up to 0° and solid ammonium chloride (15 g.) was added cautiously. The ammonia was removed from the reaction mixture under a current of nitrogen. Methanol (25 ml.) was added to the stirred mixture to destroy residual sodium. Dichloromethane (400 ml) was added and the mixture was filtered. The filtrates were evaporated in vacuo. 2-Cyclohexyl-2-hydroxymethyl-propan-1,3-diol was obtained as a colourless solid (3.2 g.).

1. temperaturewas maintained at -70°, for 1 hour
2. temperatureto warm up to 0°
3. customThe ammonia was removed from the reaction mixture under a current of nitrogen
4. additionMethanol (25 ml.) was added to the stirred mixture
5. customto destroy residual sodium
6. additionDichloromethane (400 ml) was added
7. filtrationthe mixture was filtered
8. customThe filtrates were evaporated in vacuo