反应详情

Pyrrolidine (21.1 cc) is added to a suspension of (2RS)-2-(7-chloro-2-cyano-10-phenothiazinyl)propyl methanesulphonate (72.1 g) in toluene (166 cc). The mixture is brought to 120° C. for 21 hours, and then to 150° C. for 12 hours. After cooling, the mixture is washed with distilled water (5×250 cc). The organic phase is dried over magnesium sulphate, filtered and concentrated to dryness under reduced pressure (30 mm Hg; 4 kPa) to give 7-chloro-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarbonitrile (19.2 g).

1. waitto 150° C. for 12 hours
2. temperatureAfter cooling
3. washthe mixture is washed with distilled water (5×250 cc)
4. dry with materialThe organic phase is dried over magnesium sulphate
5. filtrationfiltered
6. concentrationconcentrated to dryness under reduced pressure (30 mm Hg; 4 kPa)