Fumaric Acid → N-(2-Hydroxybenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide fumarate

Participants

Reaction Steps

N-(2-Hydroxybenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide (1.86 g) is dissolved in boiling 2-propanol (22 cc). A solution of fumaric acid (0.47 g) in 2-propanol (18 cc) under reflux is added to this solution. After cooling, the crystals formed are washed with ethyl ether (2×10 cc), filtered and dried under reduced pressure (5 mm Hg; 0.67 kPa) at 50° C. N-(2-Hydroxybenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide fumarate (1.09 g) is thereby obtained in the form of yellow crystals, m.p. about 80° C.

Provenance & Evidence