HRID704243

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID444972

Fumaric acid

C4H4O4

结构：CC(CN1CCCC1)N1c2ccccc2Sc2ccc(C(=O)NCc3ccccc3O)cc21

HCID20074856

未命名化合物

PRODUCTS

生成物

结构：CC(CN1CCCC1)N1c2ccccc2Sc2ccc(C(=O)NCc3ccccc3O)cc21.O=C(O)/C=C/C(=O)O

HCID20074855

未命名化合物

收率 46.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

2 次

PROCEDURE

实验过程

N-(2-Hydroxybenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide (1.86 g) is dissolved in boiling 2-propanol (22 cc). A solution of fumaric acid (0.47 g) in 2-propanol (18 cc) under reflux is added to this solution. After cooling, the crystals formed are washed with ethyl ether (2×10 cc), filtered and dried under reduced pressure (5 mm Hg; 0.67 kPa) at 50° C. N-(2-Hydroxybenzyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]-2-phenothiazinecarboxamide fumarate (1.09 g) is thereby obtained in the form of yellow crystals, m.p. about 80° C.

WORKUP

后处理

additionis added to this solution
temperatureAfter cooling
customthe crystals formed
washare washed with ethyl ether (2×10 cc)
filtrationfiltered
customdried under reduced pressure (5 mm Hg; 0.67 kPa) at 50° C

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f2e34afa41c24fd883f98e7f27bbb8f0
来源数据集: uspto-grants-1991_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04985419
来源说明: uspto-grants-1991_01

反应 SMILES

[OH:1][C:2]1[CH:33]=[CH:32][CH:31]=[CH:30][C:3]=1[CH2:4][NH:5][C:6]([C:8]1[CH:21]=[CH:20][C:19]2[S:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH:22]([CH3:29])[CH2:23][N:24]3[CH2:28][CH2:27][CH2:26][CH2:25]3)[C:10]=2[CH:9]=1)=[O:7].[C:34]([OH:41])(=[O:40])/[CH:35]=[CH:36]/[C:37]([OH:39])=[O:38]>CC(O)C>[C:34]([OH:41])(=[O:40])/[CH:35]=[CH:36]/[C:37]([OH:39])=[O:38].[OH:1][C:2]1[CH:33]=[CH:32][CH:31]=[CH:30][C:3]=1[CH2:4][NH:5][C:6]([C:8]1[CH:21]=[CH:20][C:19]2[S:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH:22]([CH3:29])[CH2:23][N:24]3[CH2:25][CH2:26][CH2:27][CH2:28]3)[C:10]=2[CH:9]=1)=[O:7]