Hydrochloric Acid → HCID 178430840, compound

Participants

Reaction Steps

1.2 N ethereal hydrochloric acid (0.64 cc) is added to a solution of 2-(4-methyl-2-imidazolyl)-10[(2RS)-1-(1-pyrrolidinyl)-2-propyl]phenothiazine (0.30 g) in anhydrous ethanol (3 cc). The mixture is stirred for 5 minutes and then concentrated to dryness at 40° C. under reduced pressure (30 mm Hg; 4 kPa) to give a residue which is taken up in ethyl ether (70 cc). The solid obtained is filtered off on sintered glass to give 2-(4-methyl-2-imidazolyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]phenothiazine hydrochloride (0.35 g), m.p. 210° C., in the form of a brown powder.

Provenance & Evidence