Hydrochloric Acid → HCID 178430840, compound

HRID 704253Notes

Reaction equation

HRID 704253 reaction equation
[ClH:1].[CH3:2][C:3]1[N:4]=[C:5]([C:8]2[CH:21]=[CH:20][C:19]3[S:18][C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[N:11]([CH:22]([CH3:29])[CH2:23][N:24]4[CH2:28][CH2:27][CH2:26][CH2:25]4)[C:10]=3[CH:9]=2)[NH:6][CH:7]=1>C(O)C.C(OCC)C>[ClH:1].[CH3:2][C:3]1[N:4]=[C:5]([C:8]2[CH:21]=[CH:20][C:19]3[S:18][C:17]4[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=4)[N:11]([CH:22]([CH3:29])[CH2:23][N:24]4[CH2:28][CH2:27][CH2:26][CH2:25]4)[C:10]=3[CH:9]=2)[NH:6][CH:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 178430839HCID 178430839, compound

Product 1

HCID 178430840HCID 178430840, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 3283Diethyl EtherSolvent

Procedure

1.2 N ethereal hydrochloric acid (0.64 cc) is added to a solution of 2-(4-methyl-2-imidazolyl)-10[(2RS)-1-(1-pyrrolidinyl)-2-propyl]phenothiazine (0.30 g) in anhydrous ethanol (3 cc). The mixture is stirred for 5 minutes and then concentrated to dryness at 40° C. under reduced pressure (30 mm Hg; 4 kPa) to give a residue which is taken up in ethyl ether (70 cc). The solid obtained is filtered off on sintered glass to give 2-(4-methyl-2-imidazolyl)-10-[(2RS)-1-(1-pyrrolidinyl)-2-propyl]phenothiazine hydrochloride (0.35 g), m.p. 210° C., in the form of a brown powder.

Workup

  1. concentrationconcentrated to dryness at 40° C. under reduced pressure (30 mm Hg; 4 kPa)
  2. customto give a residue which
  3. customThe solid obtained
  4. filtrationis filtered off on sintered glass

Sources & evidence

ORD record
ord-5f073810c1a4447890254d87c10c9e61
Source dataset
uspto-grants-1991_01
Patent number
US04985419

Reaction notes

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