反应详情

温度

80 °C

A mixture of 6-cyanobenzothiazole (532 mg, 3.33 mmol) and hydrazine monohydrate (1.2 ml, 24.76 mmol) in EtOH (10 ml) was heated at 80° C. under N2 atmosphere for 2 hours. The solvent was evaporated, H2O was added to the residue, and the solution was adjusted to pH˜5-7 with AcOH. The resulting yellow precipitate was filtered and washed with H2O, dried under high vacuum to yield the title compound as yellow solid (486 mg, 97%).

1. customThe solvent was evaporated
2. additionH2O was added to the residue
3. filtrationThe resulting yellow precipitate was filtered
4. washwashed with H2O
5. customdried under high vacuum