Ethanol → HCID 73454225, compound

HRID 704315Notes

Reaction equation

HRID 704315 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=O)[C:7]([NH2:9])=[O:8].C(O)C.Cl.[NH2:15][OH:16].C([O-])(=O)C.[Na+]>O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](=[N:15][OH:16])[C:7]([NH2:9])=[O:8]

Participants

6

Reactant 4

HCID 702EthanolHCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 14774041HCID 14774041, compound

Product 1

HCID 73454225HCID 73454225, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
40 °C

Procedure

A mixture of 15.5 g of 2-thienylglyoxylamide, 75 ml of water, 75 ml of ethanol, 10.4 g of hydroxylamine hydrochloride and 24.6 g of sodium acetate is stirred at 40° C. for 5 h, the volatile fractions are stripped off in vacuo, and the residue is taken up in water. The product is extracted with ethyl acetate, and the organic phase is dried and concentrated. The residue is recrystallized from a little ethyl acetate.

Workup

  1. extractionThe product is extracted with ethyl acetate
  2. customthe organic phase is dried
  3. concentrationconcentrated
  4. customThe residue is recrystallized from a little ethyl acetate

Sources & evidence

ORD record
ord-b0aba60daeb04fb09cc95f2a328c6a08
Source dataset
uspto-grants-1991_01
Patent number
US04987134

Reaction notes

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