2-Aminothiazole → HCID 178522564, compound

HRID 704341Notes

Reaction equation

[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[C:7]1([C:13]2[C:14]([OH:30])=[C:15]([C:25](OCC)=[O:26])[CH:16]=[N:17][C:18]=2[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>>[C:7]1([C:13]2[C:14]([OH:30])=[C:15]([C:25]([NH:1][C:2]3[S:3][CH:4]=[CH:5][N:6]=3)=[O:26])[CH:16]=[N:17][C:18]=2[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

Reactant 2

HCID 21552-Aminothiazole

HCID 178469733HCID 178469733, compound

Product 1

HCID 178522564HCID 178522564, compoundYield 64.1%

Procedure

Using the procedure of Example 5, 2.5 g of 2-aminothiazole and 1.6 g of the product of Step A were reacted to obtain 1.2 g of the expected product melting greater than 260° C. after crystallizing from acetonitrile.

Workup

customwere reacted

Sources & evidence

ORD record: ord-09b1b4c8368547b492e6bdda2d5008d9
Source dataset: uspto-grants-1991_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04987140

Reaction notes

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