Potassium Carbonate → HCID 14881545, compound

Participants

Reaction Steps

A solution of 320 mg of 2-amino-5-mercapto-1,3,4-thiadiazole, 430 mg of 1-bromo-4-phenylbutane and 350 mg of potassium carbonate in 5 ml of N,N-dimethylformamide was stirred overnight at room temperature. After dilution with ethyl acetate, the reaction mixture was washed in sequence with water, 1N sodium hydroxide, water and saturated aqueous solution of sodium chloride, then dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue obtained was recrystallized from ethyl acetate to give 300 mg of 2-amino-5-[(4-phenylbutyl)thio]-1,3,4-thiadiazole. Melting point 111° C.

Provenance & Evidence