反应详情

A solution of the 3-(4-methoxyphenyl)propionic acid in 100 ml of anhydrous ether was added dropwise to a suspension of 1.10 g of lithium aluminum hydride in 50 ml of anhydrous ether with stirring at room temperature over 20 minutes. After stirring at room temperature for 30 minutes, the mixture was refluxed for 1 hours. After cooling, water was added with ice cooling, and the mixture was made acidic by further addition of 10% hydrochloric acid and then extracted with ether. The organic layer was washed with saturated aqueous solution of sodium chloride, driven over anhydrous magnesium sulfate and concentrated under reduced pressure to give 5.06 g of 3-(4-methoxyphenyl)propanol.

1. stirringAfter stirring at room temperature for 30 minutes
2. temperaturethe mixture was refluxed for 1 hours
3. temperatureAfter cooling
4. extractionextracted with ether
5. washThe organic layer was washed with saturated aqueous solution of sodium chloride
6. concentrationconcentrated under reduced pressure