HCID 4191957, compound → N-Butylpiperazine-1-carboxamide

HRID 704409Notes

Reaction equation

HRID 704409 reaction equation
C([N:8]1[CH2:13][CH2:12][N:11]([C:14]([NH:16][CH2:17][CH2:18][CH2:19][CH3:20])=[O:15])[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[CH2:17]([NH:16][C:14]([N:11]1[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)=[O:15])[CH2:18][CH2:19][CH3:20]

Participants

4

Reactant 1

HCID 4191957HCID 4191957, compound

Product 1

HCID 20074044N-Butylpiperazine-1-carboxamideYield 116.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10% Palladium-on-carbon (250 mg) was added to a solution of 2.8 g of 1-benzyl-4-butylaminocarbonylpiperazine in 15 ml of ethanol, and catalytic reduction was carried out until cessation of hydrogen absorption. The catalyst was then filtered off, and the filtrate was concentrated under reduced pressure to give 2.2 g of 1-butylaminocarbonylpiperazine. This product was submitted to the next step without purification.

Workup

  1. customwas carried out until cessation of hydrogen absorption
  2. filtrationThe catalyst was then filtered off
  3. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-4a3ab0ea5deb435d90e4711a1aa6fea4
Source dataset
uspto-grants-1991_01
Patent number
US04987132

Reaction notes

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