反应详情

3-Metyl-3-phenylbutanol (0.82 g) was refluxed in 47% hydrobromic acid (5 ml) under heating for 7 hours. To the reaction solution was added water and the solution was extracted with ether. After washing with a saturated aqueous solution of sodium chloride, the ether layer was dried over anhydrous magnesium sulfate, and the residue was then subjected to silica gel column chromatography. Elution with a hexane - ethyl acetate 10:1) mixture gave 1.02 of 1-bromo-3-methyl-3-phenylbutane.

1. temperatureunder heating for 7 hours
2. extractionthe solution was extracted with ether
3. washAfter washing with a saturated aqueous solution of sodium chloride
4. dry with materialthe ether layer was dried over anhydrous magnesium sulfate
5. washElution with a hexane - ethyl acetate 10:1) mixture