反应详情

温度

80 °C

A mixture of iron powder (115 g), acetic acid (29 g) and water (551 g) was heated at 80° C., and a solution of the compound (III) (132 g) in acetic acid (200 g) was dropwise added thereto in 1 hour, followed by heating under reflux for 5 hours. The reaction mixture was filtered to remove insoluble materials, and the filtrate was extracted with ethyl acetate. The extract was concentrated under reduced pressure. The residue was distilled off under reduced pressure to give 4-chloro-2-fluoro-5-(pentyloxycarbonylmethyloxy)aniline (Compound (II)) (90 g). Yield, 75 b.p., 145°-149° C./0.4 mmHg. m.p., 32°-3420 C.

1. temperatureby heating
2. temperatureunder reflux for 5 hours
3. filtrationThe reaction mixture was filtered
4. customto remove insoluble materials
5. extractionthe filtrate was extracted with ethyl acetate
6. concentrationThe extract was concentrated under reduced pressure
7. distillationThe residue was distilled off under reduced pressure