Sodium Hydroxide → HCID 9815420, compound

HRID 704551Notes

Reaction equation

HRID 704551 reaction equation
[OH-].[Na+].[N:3]1([CH2:8][C:9]#[C:10][CH2:11][NH:12][C:13]([NH:15]C(=O)C2C=CC=CC=2)=[O:14])[CH2:7][CH2:6][CH2:5][CH2:4]1>>[N:3]1([CH2:8][C:9]#[C:10][CH2:11][NH:12][C:13]([NH2:15])=[O:14])[CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 15167055HCID 15167055, compound

Product 1

HCID 9815420HCID 9815420, compound

Procedure

To a solution of sodium hydroxide (0.1 mol) at 80° C. is added N-[[[4-(1-pyrrolidinyl)-2-butynyl]amino]-carbonyl]-benzamide (4.3 g, 0.015 mol) (Example 1f) in one portion. The solution is allowed to stir for 12 minutes, cooled, extracted with chloroform, dried over magnesium sulfate and concentrated to give an oil which solidifies upon standing; mp 71°-73° C.

Workup

  1. temperaturecooled
  2. extractionextracted with chloroform
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated
  5. customto give an oil which

Sources & evidence

ORD record
ord-a49f4496bb6d494aacac8bd4e60fca60
Source dataset
uspto-grants-1991_01
Patent number
US04988688

Reaction notes

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