Benzylamine → 1-methyl-5-phenyl-3-{(phenylmethyl)-amino}-1H-1,5-benzodiazepine-2,4(3H, 5H)-dione

HRID 704557Notes

Reaction equation

Br[CH:2]1[C:8](=[O:9])[N:7]([CH3:10])[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[N:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:3]1=[O:21].[CH2:22]([NH2:29])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>O>[CH3:10][N:7]1[C:6]2[CH:11]=[CH:12][CH:13]=[CH:14][C:5]=2[N:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[C:3](=[O:21])[CH:2]([NH:29][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:8]1=[O:9]

Participants

Conditions

Temperature: 100 °C

Procedure

A mixture of 50 mg of the product of Step B and 2 ml of benzylamine was heated at 100° C. for 3 hours and the reaction medium was poured into water. The product obtained was separated, washed, and dried in the presence of phosphoric anhydride to obtain 50 mg of the sought product.

Workup

customThe product obtained
customwas separated
washwashed
dry with materialdried in the presence of phosphoric anhydride

Sources & evidence

ORD record: ord-eedb9b22640b40bb8f4133c725dde4e3
Source dataset: uspto-grants-1991_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04988692

Reaction notes

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