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4-Amino-M-cresol hydrochloride → 1-(4-Hydroxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo-[3,2-c]cinnoline hydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Amino-M-cresol hydrochloride | HCID 459234 | — |
| 反応物 | 4-Chloro-3-(2-chloroethyl)-8-methylcinnoline | HCID 20072762 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 1-(4-Hydroxy-2-methylphenyl)-6-methyl-2,3-dihydropyrrolo-[3,2-c]cinnoline hydrochloride | HCID 20072760 | — |
反応手順
3-(2-Chloroethyl)-4-chloro-8-methylcinnoline (2 g, 0.0083 mol) and 4-hydroxy-2-methylaniline hydrochloride (1.32 g, 0.0083 mol) in isopropanol (50 ml) were heated under reflux in a nitrogen atmosphere for 20 hours. The solid obtained was collected by filtration and dried. Recrystallization from isopropanol/ethanolic HCl gave the title compound as a partial hydrate, 0.64 g, m.p. 292-294°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04988695 |
| 出典データセット | uspto-grants-1991_01 |
| ORD ID | ord-7c1afd5036694aa8a5e45f726ac3f874 |
| 出典メモ | uspto-grants-1991_01 |