反应详情

3-(2-Chloroethyl)-4-chloro-8-methylcinnoline (2 g, 0.0083 mol) and 4-hydroxy-2-methylaniline hydrochloride (1.32 g, 0.0083 mol) in isopropanol (50 ml) were heated under reflux in a nitrogen atmosphere for 20 hours. The solid obtained was collected by filtration and dried. Recrystallization from isopropanol/ethanolic HCl gave the title compound as a partial hydrate, 0.64 g, m.p. 292-294°.

1. temperatureunder reflux in a nitrogen atmosphere for 20 hours
2. customThe solid obtained
3. filtrationwas collected by filtration
4. customdried
5. customRecrystallization from isopropanol/ethanolic HCl