反应详情

A solution of 1,4-dioxaspiro[4,5]decane-8-acetic acid (36.54 g) (Example G) in 750 ml of a 1:1 mixture of a 10% solution of hydrochloric acid:acetone is refluxed under nitrogen for four hours. The mixture is concentrated in vacuo and the residue extracted with chloroform. The organic extract is dried (magnesium sulfate) and evaporated to leave the title compound as a yellow oil which can be used without further purification.

1. concentrationThe mixture is concentrated in vacuo
2. extractionthe residue extracted with chloroform
3. extractionThe organic extract
4. dry with materialis dried (magnesium sulfate)
5. customevaporated