Benzaldehyde → ethyl (Z)-2-(ethoxyisobutylphosphinoyl)methyl-3-phenylpropenoate

Temperature

-78 °C

Under a nitrogen atmosphere, 7.3 ml (11 millimoles) of 1.5 M butyllithium-hexane was added dropwise to a solution of 1.5 ml (11 millimoles) of diisopropylamine in 20 ml of dry tetrahydrofuran. The mixture was cooled to -78° C. in a dry ice-methanol bath, and 1.50 g (10 millimoles) of ethyl isobutylphosphinate and then 2.46 g (10.4 millimoles) of ethyl 2-diethoxyphosphinoylpropenoate were added. The mixture was stirred at 0° C. for 30 minutes. The mixture was cooled to -30 ° C., and 1.1 ml (11 millimoles) of benzaldehyde was added. The mixture was stirred at -30° C. for 3 hours, and ovenight at room temperature. A saturated aqueous solution of ammonium chloride (50 ml) was added to the reaction mixture, and the mixture was extracted three times with 50 ml of ethyl acetate each time. The combined organic layers were washed with 20 ml of a saturated aqueous solution of sodium chloride and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by medium-pressure liquid chromatography [Lobar column (a product of E. Merck & Co.), size C, Lichroprep SI 60, ethyl acetate]. The first fraction was evaporated to give 1.00 g (yield 30%) of ethyl (Z)-2-(ethoxyisobutylphosphinoyl)methyl-3-phenylpropenoate as a colorless oil.

1. temperatureThe mixture was cooled to -30 ° C.
2. stirringThe mixture was stirred at -30° C. for 3 hours
3. customat room temperature
4. extractionthe mixture was extracted three times with 50 ml of ethyl acetate each time
5. washThe combined organic layers were washed with 20 ml of a saturated aqueous solution of sodium chloride
6. dry with materialdried over anhydrous magnesium sulfate
7. customThe solvent was evaporated under reduced pressure
8. customthe residue was purified by medium-pressure liquid chromatography [Lobar column (a product of E
9. customThe first fraction was evaporated

ORD record

ord-2f9228cf90ca4efe8183b9d16f1e0cf2

Source dataset

uspto-grants-1991_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04988681