反应详情

温度

64 °C

A mixture of 6-amino-8-methyl-3,4-dihydro-2(1H)-quinolinone (19.4 g), bis(2-bromoethyl)amine hydrobromide (41 g) and methanol (140 ml) was stirred for 13 hours at 64° C. After cooling, sodium carbonate (5.83 g) was added thereto and the mixture was stirred for 9 hours at 70° C. After cooling, the resulting precipitate was collected by filtration and the residue was washed with methanol to give 3,4-dihydro-8-methyl-6-(1-piperazinyl)-2(1H)-quinolinone hydrobromide (21.6 g).

1. temperatureAfter cooling
2. stirringthe mixture was stirred for 9 hours at 70° C
3. temperatureAfter cooling
4. filtrationthe resulting precipitate was collected by filtration
5. washthe residue was washed with methanol