HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 704620Generated: October 27, 2026
Sodium Carbonate → 3,4-dihydro-8-methyl-6-(1-piperazinyl)-2(1H)-quinolinone hydrobromide
https://huagongshe.com/reaction/704620
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Ethanamine, 2-bromo-N-(2-bromoethyl)-, hydrobromide (1:1) | HCID 12692731 | — |
| Reactant | 6-Amino-8-methyl-3,4-dihydroquinolin-2(1H)-one | HCID 14627549 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3,4-dihydro-8-methyl-6-(1-piperazinyl)-2(1H)-quinolinone hydrobromide | HCID 20072868 | 60.1% |
Reaction Steps
A mixture of 6-amino-8-methyl-3,4-dihydro-2(1H)-quinolinone (19.4 g), bis(2-bromoethyl)amine hydrobromide (41 g) and methanol (140 ml) was stirred for 13 hours at 64° C. After cooling, sodium carbonate (5.83 g) was added thereto and the mixture was stirred for 9 hours at 70° C. After cooling, the resulting precipitate was collected by filtration and the residue was washed with methanol to give 3,4-dihydro-8-methyl-6-(1-piperazinyl)-2(1H)-quinolinone hydrobromide (21.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04988698 |
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| Source dataset | uspto-grants-1991_01 |
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| ORD ID | ord-217e611015d54f56bbe1fca582973d06 |
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| Source note | uspto-grants-1991_01 |
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