Methylamine → HCID 14760633, compound

HRID 704648Notes

Reaction equation

HRID 704648 reaction equation
[C:1]1([CH:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[O:8][C:9]2[C:14](=[O:15])[CH:13]=[C:12]([CH2:16][OH:17])O[CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:24][NH2:25]>CO>[C:1]1([CH:7]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[O:8][C:9]2[C:14](=[O:15])[CH:13]=[C:12]([CH2:16][OH:17])[N:25]([CH3:24])[CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 6329MethylamineHCID 14306387HCID 14306387, compound

Product 1

HCID 14760633HCID 14760633, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3.035 g of 3-diphenylmethoxy-6-hydroxymethyl-4-pyrone in 20 ml of methanol is added 50 ml of 40% aqueous methylamine solution, and the mixture is stirred for 4 hours. The reaction mixture is condensed under reduced pressure to a volume of 15 ml, and the resulting crystal is collected by filtration, washed with a small amounts of water and ethyl acetate in this sequence, and dried under reduced pressure to give 2.04 g of the title compound.

Workup

  1. customcondensed under reduced pressure to a volume of 15 ml
  2. filtrationthe resulting crystal is collected by filtration
  3. washwashed with a small amounts of water and ethyl acetate in this sequence
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-cd77939740b5488a9ea268b82d6ec1e6
Source dataset
uspto-grants-1991_01
Patent number
US04988686

Reaction notes

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