Tetrahydrofuran → HCID 15158211, compound

HRID 704693Notes

Reaction equation

HRID 704693 reaction equation
[CH:1]1([C:7]2[C:12](C(=O)C)=[CH:11][CH:10]=[CH:9][C:8]=2[CH:16]=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[C:19]([O:23][Al](OC(C)(C)C)OC(C)(C)C)(C)(C)C.[Li+].C1C[O:39]CC1>>[CH:11]1([CH2:12][C:7]([C:1]2[CH:2]=[CH:3][C:4]([CH2:19][OH:23])=[CH:5][CH:6]=2)=[O:39])[CH2:10][CH2:9][CH2:8][CH2:16]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 16710494Lithium tri-tert-butoxyaluminohydrideHCID 86744543HCID 86744543, compound

Product 1

HCID 15158211HCID 15158211, compoundYield 90%

Procedure

Following the procedure of Example F, the product of Example K 2.5 g (0.011mole) was reduced in 35 mls of THF containing 3.5 g of lithium tri-tert-butoxy aluminum hydride to give 2.25 g of the title compound (90% yield).

Sources & evidence

ORD record
ord-734cbb120dd145c691533d86bb817ff1
Source dataset
uspto-grants-1991_01
Patent number
US04988707

Reaction notes

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