Benzoic Acid → HCID 178459368, compound

HRID 704759Notes

Reaction equation

[OH:1][C:2]1[C:11]2[C:6](=[C:7]([C:12]([F:15])([F:14])[F:13])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH:16]([OH:19])[CH2:17][CH3:18])[C:3]=1[C:20]([NH:22][C:23]1[S:24][CH:25]=[CH:26][N:27]=1)=[O:21].[C:28](O)(=[O:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>>[C:28]([O:19][CH:16]([C:4]1[C:3]([C:20]([NH:22][C:23]2[S:24][CH:25]=[CH:26][N:27]=2)=[O:21])=[C:2]([OH:1])[C:11]2[C:6](=[C:7]([C:12]([F:14])([F:13])[F:15])[CH:8]=[CH:9][CH:10]=2)[N:5]=1)[CH2:17][CH3:18])(=[O:35])[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1

Participants

Reactant 2

HCID 243Benzoic Acid

HCID 178458925HCID 178458925, compound

Product 1

HCID 178459368HCID 178459368, compoundYield 73.7%

Procedure

Using the procedure of Example 15, 5 g of 4-hydroxy-2(1-hydroxypropyl)-N-(2-thiazolyl)-8-trifluoromethyl-3-quinoline carboxamide and 1.7 g of benzoic acid were reacted to obtain 4.65 g of 2-[1-(benzoyloxy)-propyl]-4-hydroxy-N-(2-thiazolyl)-8-(trifluoromethyl)-3-quinoline carboxamide melting at 230° C.

Workup

customwere reacted

Sources & evidence

ORD record: ord-9049614d50004688a74b5dafebf7d6aa
Source dataset: uspto-grants-1991_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04988708

Reaction notes

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