1,1'-Carbonyldiimidazole → HCID 86743608, compound

HRID 704771Notes

Reaction equation

HRID 704771 reaction equation
[CH3:1][NH:2][C@@H:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][C@H:4]1[N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1.[C:17]1([C:23]2[S:27][C:26]([CH2:28][C:29]([OH:31])=O)=[CH:25][CH:24]=2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(N1C=CN=C1)(N1C=CN=C1)=O>>[N:12]1([C@@H:4]2[CH2:5][C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[C@H:3]2[N:2]([CH3:1])[C:29](=[O:31])[CH2:28][C:26]2[S:27][C:23]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)=[CH:24][CH:25]=2)[CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

4

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 12323246HCID 12323246, compoundHCID 14126789HCID 14126789, compound

Product 1

HCID 86743608HCID 86743608, compoundYield 68.6%

Procedure

Using the procedure of Step C of Example 1, 0.432 g of the product of Step B of Example 1, 0.567 g of 5-phenyl-2-thiophene-acetic acid and 0.422 g of carbonyldiimidazole were reacted to obtain 0.571 g of trans-(±)- N-[2,3-dihydro-2-(1-pyrrolidinyl)-1H-inden-1-yl]-N-methyl-5-phenyl-2-thiophene-acetamide and then 0.457 g of its hydrochloride melting at ≃249° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-9f0d84d36e494b85ba1f252daf0f1637
Source dataset
uspto-grants-1991_01
Patent number
US04988727

Reaction notes

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