1-Naphthaleneacetic Acid → HCID 3087827, compound

HRID 704772Notes

Reaction equation

HRID 704772 reaction equation
[CH3:1][NH:2][C@@H:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][C@H:4]1[N:12]1[CH2:16][CH2:15][CH2:14][CH2:13]1.[C:17]1([CH2:27][C:28]([OH:30])=O)[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH:20]=[CH:19][CH:18]=1.C(N1C=CN=C1)(N1C=CN=C1)=O>>[N:12]1([C@@H:4]2[CH2:5][C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[C@H:3]2[N:2]([CH3:1])[C:28](=[O:30])[CH2:27][C:17]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH:20]=[CH:19][CH:18]=2)[CH2:13][CH2:14][CH2:15][CH2:16]1

Participants

4

Reactant 3

HCID 68621-Naphthaleneacetic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 14126789HCID 14126789, compound

Product 1

HCID 3087827HCID 3087827, compound

Procedure

Using the procedure of Step C of Example 1, 0.432 g of the product of the product of Step B of Example 1, 0.484 g of 1-naphthylacetic acid and 0.422 g of carbonyldiimidazole were reacted to obtain 0.718 g of trans (+) N-[2,3-dihydro-2-(1-pyrrolidinyl)-1H-inden-1-yl]-N-methyl-1-naphthalene-acetamide melting at 127° C. and then 0.655 g of the base were reacted to obtain 0.533 g of its hydrochloride melting at ≃240° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-39cdffc8809f478398836688a9d71ef9
Source dataset
uspto-grants-1991_01
Patent number
US04988727

Reaction notes

Loading…