Trifluoroacetic acid → BW B218C

HRID 704812Notes

Reaction equation

HRID 704812 reaction equation
C([O:5][C:6]([N:8]([CH:17]([CH3:33])[CH:18]=[CH:19][C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:21]=1)[O:9]C(OC(C)(C)C)=O)=O)(C)(C)C.F[C:35](F)(F)C(O)=O>C(Cl)Cl>[CH3:33][CH:17]([N:8]([C:6](=[O:5])[CH3:35])[OH:9])/[CH:18]=[CH:19]/[C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[CH:21]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 53706782HCID 53706782, compound

Product 1

HCID 6439376BW B218C

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from step (e) (1.97 g) was taken up in methylene chloride (12 ml) and trifluoroacetic acid (3 ml) was added under N2. The mixture was stirred for 1 hour at room temperature and then stripped to give the hydroxylamine as a viscous tan/red oil which was taken up in methylene chloride (5 ml).

Sources & evidence

ORD record
ord-78d9bb44a84c4f518989a8bd3e638527
Source dataset
uspto-grants-1991_01
Patent number
US04988733

Reaction notes

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