反应详情

温度

80 °C

A suspension of 1-[(3-amino-2-chloro-4-quinolinyl)amino]-2-methyl-2-propanol (5 g from EXAMPLE 13) in xylene (50 mL) and triethylorthoformate (5 mL) was heated at 80° C. until no starting material remained as determined by thin layer chromatography. The resulting solution was cooled, and the precipitated product was isolated by filtration and washed with xylene (3×10 mL).

1. temperatureThe resulting solution was cooled
2. customthe precipitated product was isolated by filtration
3. washwashed with xylene (3×10 mL)