HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 14801892, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Piperazinylpyrimidine dihydrochloride | HCID 11680272 | — |
| Reactant | 3-Bromopropyl 2,2-dimethylpropanoate | HCID 12326039 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 14801892 | HCID 14801892 | 164.1% |
Reaction Steps
To a stirred solution of N-(2-pyrimidinyl)piperazine dihydrochloride (4.25 g, 0.0179 mol) and triethylamine (6.06 g, 0.06 mol) in DMF was added 3-bromopropyl pivalate (4.0 g, 0.0179 mol) and the solution was stirred overnight at room temperature. The solvent was evaporated and the residue dissolved in CH2Cl2. The CH2Cl2 extract was washed with water, dried (anhydrous Na2SO4) and evaporated to afford 9.0 g of crude title compound. Purification by HPLC and conversion to the dihydrochloride with ethereal HCl yielded the product, mp. 178°-180° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04988814 |
| Source dataset | uspto-grants-1991_01 |
| ORD ID | ord-a0d49e44e65541a293c545a76f849936 |
| Source note | uspto-grants-1991_01 |