Sodium Hydroxide → Sodium 2-(2-tritylamino-4-thiazolyl)-2-(1-methylethoxyimino)-acetate

HRID 704941Notes

Reaction equation

HRID 704941 reaction equation
[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([C:26](=[N:32][O:33][CH:34]([CH3:36])[CH3:35])[C:27]([O:29]CC)=[O:28])[N:25]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+:38].[Na]>O1CCOCC1>[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24]([C:26](=[N:32][O:33][CH:34]([CH3:36])[CH3:35])[C:27]([O-:29])=[O:28])[N:25]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Na+:38]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 5360545SodiumHCID 54071115Ethyl 2-(2-tritylamino-4-thiazolyl)-2-(1-methylethoxyimino)-acetate

Product 1

HCID 86736514Sodium 2-(2-tritylamino-4-thiazolyl)-2-(1-methylethoxyimino)-acetate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 27.7 g of the product of Step D, 150 ml of dioxane and 65 ml of 2N sodium hydroxide was refluxed for 2 hours and the mixture was cooled for crystallization of a sodium salt. The mixture was vacuum filtered and the recovered product was rinsed with a 1-1 ether-dioxane mixture and dried to obtain 16.85 g of raw sodium 2-(2-tritylamino-4-thiazolyl)-2-(1-methylethoxyimino)-acetate.

Workup

  1. temperaturewas refluxed for 2 hours
  2. filtrationfiltered
  3. washthe recovered product was rinsed with a 1-1 ether-dioxane mixture
  4. customdried

Sources & evidence

ORD record
ord-0e9b86126cf14ad0953c90de3f7140e7
Source dataset
uspto-grants-1991_01
Patent number
US04988816

Reaction notes

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