反应详情

To a solution of 6-bromo-5-fluoropicolinic acid (1.0 equiv.) in methanol (0.2 M) was added H2SO4 (4.2 equiv.) and the reaction was stirred at room temperature for two hours. Upon completion of the reaction as monitored by LC/MS, the reaction was diluted with ethyl acetate and quenched slowly with saturated aqueous NaHCO3. The reaction was poured into a separatory funnel and extracted with ethyl acetate. The organic phase was dried with magnesium sulfate, filtered, and concentrated in vacuo to provide methyl 6-bromo-5-fluoropicolinate as a white solid (>99%). LC/MS=233.9/235.9 (M+H), Rt=0.69 min.

1. customUpon completion of the reaction
2. customquenched slowly with saturated aqueous NaHCO3
3. additionThe reaction was poured into a separatory funnel
4. extractionextracted with ethyl acetate
5. dry with materialThe organic phase was dried with magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo