Trifluoroacetic acid → HCID 178430838, compound

HRID 705337Notes

Reaction equation

HRID 705337 reaction equation
[CH:1]1([C:4]2[C:5]([N:26](CC3C=CC(OC)=CC=3)[S:27]([CH3:30])(=[O:29])=[O:28])=[CH:6][C:7]3[O:11][C:10]([C:12]4[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=4)=[C:9]([C:19]4[NH:20][CH:21]=[C:22]([CH3:24])[N:23]=4)[C:8]=3[CH:25]=2)[CH2:3][CH2:2]1.FC(F)(F)C(O)=O>C(Cl)Cl>[CH:1]1([C:4]2[C:5]([NH:26][S:27]([CH3:30])(=[O:28])=[O:29])=[CH:6][C:7]3[O:11][C:10]([C:12]4[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=4)=[C:9]([C:19]4[NH:20][CH:21]=[C:22]([CH3:24])[N:23]=4)[C:8]=3[CH:25]=2)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 178490930HCID 178490930, compound

Product 1

HCID 178430838HCID 178430838, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared according to the procedure described in Example 1O using the compound prepared in Example 2B, (0.64 g, 1.17 mmol) and 20% trifluoroacetic acid in CH2Cl2. The title compound was isolated as a yellow solid (0.18 g, 35%). MS (ESI+) m/z 426 (M+H)+.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-6f4e7143eb2e42009fd0f002cffaa7ef
Source dataset
uspto-grants-2015_11
Patent number
US09173887B2

Reaction notes

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