反应详情

Tert-butyl 4-cyclopropylpyridin-3-ylcarbamate (393 mg, 1.677 mmol) was dissolved in 4 M HCl in dioxane (30 mL), and stirred at room temperature for 1 hour, the reaction rapidly becoming a white heterogeneous mixture. TLC (SiO2, 5% methanol/CH2Cl2) showed reaction complete after 1 hour. The solvent was removed by rotary evaporation, the residue was triturated with diethyl ether and vacuum filtered to collect the solid, and the solid was dried in a vacuum oven at 50° C. for 1 hour to afford the product as a beige solid (325 mg).

1. customthe reaction
2. customreaction complete after 1 hour
3. customThe solvent was removed by rotary evaporation
4. customthe residue was triturated with diethyl ether and vacuum
5. filtrationfiltered
6. customto collect the solid
7. customthe solid was dried in a vacuum oven at 50° C. for 1 hour