O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamine → HCID 86710153, compound

HRID 705365Notes

Reaction equation

HRID 705365 reaction equation
[CH:1]1([C:4]2[CH:9]=[CH:8][N:7]=[CH:6][C:5]=2[N:10]([CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[S:11]([CH3:14])(=[O:13])=[O:12])[CH2:3][CH2:2]1.[C:20]1([CH3:33])[CH:25]=[C:24]([CH3:26])[CH:23]=[C:22]([CH3:27])[C:21]=1[S:28]([O:31][NH2:32])(=[O:30])=[O:29]>ClCCl>[CH3:27][C:22]1[CH:23]=[C:24]([CH3:26])[CH:25]=[C:20]([CH3:33])[C:21]=1[S:28]([O-:31])(=[O:30])=[O:29].[NH2:32][N+:7]1[CH:8]=[CH:9][C:4]([CH:1]2[CH2:3][CH2:2]2)=[C:5]([N:10]([CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[S:11]([CH3:14])(=[O:12])=[O:13])[CH:6]=1

Participants

4

Reactant 2

HCID 11830845O-(2,4,6-Trimethylbenzenesulfonyl)hydroxylamineHCID 86710155HCID 86710155, compound

Product 1

HCID 86710153HCID 86710153, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of N-(4-cyclopropylpyridin-3-yl)-N-isopentylmethanesulfonamide (Example 17G, 474 mg, 1.68 mmol) in dichloromethane (3 mL) at 0° C. was treated with the solution of O-(mesitylsulfonyl)hydroxylamine (solution used directly from Example 17H). The solution was immediately warmed to room temperature and stirred for 1 hour. The solution was then used directly in Example 17K.

Sources & evidence

ORD record
ord-d574285215e14fcea7b27ec79c4e4f78
Source dataset
uspto-grants-2015_11
Patent number
US09173887B2

Reaction notes

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