反应详情

温度

60 °C

4 mL of DMF and trimethylsilyl bromide (1 mL) were added to the mixture (170 mg) of monomethyl(3-nitrophenyl)phosphonate and dimethyl ester, and stirred at 60° C. for 2 hours. After removing a solvent, the mixture was dissolved in a mixed solvent of water and methanol. Pd/C in catalyst quantity was added thereto and stirred under hydrogen atmosphere overnight. After filtering out the catalyst, a solvent was removed to obtain a crude product of (3-aminophenyl)phosphonic acid.

1. customAfter removing a solvent
2. dissolutionthe mixture was dissolved in a mixed solvent of water and methanol
3. additionPd/C in catalyst quantity was added
4. stirringstirred under hydrogen atmosphere overnight
5. filtrationAfter filtering out the catalyst
6. customa solvent was removed