Water → HCID 49856399, compound

HRID 705505Notes

Reaction equation

HRID 705505 reaction equation
[N:1]1([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=[CH:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1.[OH2:22]>CO>[OH2:22].[N:1]1([C:6]2[CH:7]=[C:8]3[C:13](=[CH:14][CH:15]=2)[N:12]=[C:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:10]=[CH:9]3)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 962WaterHCID 248987326-(1H-Imidazol-1-yl)-2-phenylquinazoline

Product 1

HCID 49856399HCID 49856399, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

50 mg of 6-(1H-imidazol-1-yl)-2-phenylquinazoline are suspended in 2 mL of methanol, the suspension is heated at reflux for a few minutes, and then filtered and left to evaporate slowly at room temperature, at rest. The crystals obtained are analysed. XRPD: Form C. TGA: weight loss: 6.32% (theoretical value for C17H12N4.H2O: 6.2%), TGA-IR in agreement with the IR spectrum of H2O for the released vapours.

Workup

  1. temperaturethe suspension is heated
  2. temperatureat reflux for a few minutes
  3. filtrationfiltered
  4. waitleft
  5. customto evaporate slowly at room temperature, at rest
  6. customThe crystals obtained

Sources & evidence

ORD record
ord-61d7491b00d641fcaf4e6c9f0042903d
Source dataset
uspto-grants-2015_11
Patent number
US09174966B2

Reaction notes

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