Tert-butyl 3-(6-bromo-2-methoxypyridin-3-yl)acrylate → Tert-butyl 3-(6-bromo-2-methoxypyridin-3-yl)propanoate

Participants

Reaction Steps

10% platinum-activated carbon was added to a solution of tert-butyl 3-(6-bromo-2-methoxypyridin-3-yl)acrylate (727 mg) in ethyl acetate (7.3 mL), and the mixture was stirred for four hours in a hydrogen atmosphere. The reaction solution was filtered through celite and the filtrate was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=8:1) to give the title compound as a colorless oil (657 mg, 90%).

Provenance & Evidence