反应详情

10% platinum-activated carbon was added to a solution of tert-butyl 3-(6-bromo-2-methoxypyridin-3-yl)acrylate (727 mg) in ethyl acetate (7.3 mL), and the mixture was stirred for four hours in a hydrogen atmosphere. The reaction solution was filtered through celite and the filtrate was concentrated. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=8:1) to give the title compound as a colorless oil (657 mg, 90%).

1. filtrationThe reaction solution was filtered through celite
2. concentrationthe filtrate was concentrated
3. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=8:1)