HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 705700Generated: October 30, 2026
Water → 7-Chloro-1,3-dioxaindane-5-carbaldehyde
https://huagongshe.com/reaction/705700
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | 3-Chloro-4,5-dihydroxybenzaldehyde | HCID 2468182 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-Chloro-1,3-dioxaindane-5-carbaldehyde | HCID 676492 | 412.2% |
Reaction Steps
To a solution of 3-chloro-4,5-dihydroxy-benzaldehyde (8.0 g, 46 mmol) and BrClCH2 (89 g, 0.70 mol) in dry DMF (300 mL) was added Cs2CO3 (228 g, 0.700 mol). The mixture was stirred at 60° C. overnight and was then poured into water. The resulting mixture was extracted with ethyl acetate. The combined extracts were washed with brine, dried over Na2SO4 and concentrated under reduced pressure to afford the title compound (35.0 g; 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09174967B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-1dbf80a588e649d3afa474af64697a63 |
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| Source note | uspto-grants-2015_11 |
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