反应详情

To a solution of 7-chloro-1,3-benzodioxole-5-carbaldehyde (35.0 g, 0.19 mol) in THF (300 mL) was added NaBH4 (14.5 g, 0.38 mol) in portions at 0° C. The mixture was stirred at this temperature for 30 min and then poured into aqueous NH4Cl solution. The organic layer was separated, and the aqueous phase was extracted with EtOAc (3×150 mL). The combined extracts were dried over Na2SO4 and evaporated under reduced pressure to afford the title compound (34.5 g; 98%), which was directly used in the next step.

1. customThe organic layer was separated
2. extractionthe aqueous phase was extracted with EtOAc (3×150 mL)
3. dry with materialThe combined extracts were dried over Na2SO4
4. customevaporated under reduced pressure