Water → Carbamic acid, N-[4-bromo-2-(trifluoromethoxy)phenyl]-, phenylmethyl ester

4-Bromo-2-(trifluoromethoxy)aniline (1.0 g, 3.9 mmol) was dissolved in dry toluene (25 mL), sodium carbonate (0.621 g, 5.86 mmol) and benzyl chloroformate (0.669 mL, 4.69 mmol) was added and the mixture stirred under nitrogen at room temperature for 22 hours. The reaction was then heated to 80° C. and stirred at this temperature for 17 hours and then heated further to reflux and stirred for 22 hours. Water (100 mL) was added to the called mixture, the aqueous phase separated and washed with ethyl acetate (2×100 mL). The combined organic extracts were washed with 0.5 M aq, citric acid (70 mL), water (70 mL), brine (70 mL), dried (MgSO4), filtered and concentrated in vacua to give a pink solid. The crude material was purified by silica gel chromatography (40 g Si cartridge, 0-20% EtOAc in 40-60° C. petroleum benzine) to give the title compound (I46) (1.153 g, 76% yield) as a white solid; 1H NMR (400 MHz, CDCl3) δ 8.15 (d, J=8.7 Hz, 1H), 7.44-7.36 (m, 7H), 6.95 (s, 1H), 5.22 (s, 2H). LCMS Method C: rt 6.67 min; m/z 389.9 [M−H]−.

1. temperatureThe reaction was then heated to 80° C.
2. stirringstirred at this temperature for 17 hours
3. temperatureheated further
4. temperatureto reflux
5. stirringstirred for 22 hours
6. customthe aqueous phase separated
7. washwashed with ethyl acetate (2×100 mL)
8. washThe combined organic extracts were washed with 0.5 M aq
9. dry with materialcitric acid (70 mL), water (70 mL), brine (70 mL), dried (MgSO4)
10. filtrationfiltered
11. concentrationconcentrated in vacua
12. customto give a pink solid
13. customThe crude material was purified by silica gel chromatography (40 g Si cartridge, 0-20% EtOAc in 40-60° C. petroleum benzine)

ORD record

ord-ea4346be941f4e89a712905723ada919

Source dataset

uspto-grants-2015_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09174946B2